modem.ucsd.eduWei Wang's Group

Wang lab Principles behind gene regulation and protein-protein interactions Home Publications People Software Taiji DBPnet EpiTensor epigram STAR More Courses -- Positions Contact GITHUB Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation Constructing 3D interaction maps from 1D epigenomes Predicting the human epigenome from DNA motifs Previous Next We are interested in understanding the regulatory mechanisms underlying cell fate decision. Especially, we take a multi-scale approach that integrates computational and experimental investigation of epigenetic regulation in cell fate decision from molecular level to genomic level then to systems level. We aim to build computational and theoretical models to uncover fundamental principles that govern cell fate decision in development and cellular reprogramming and design strategies to intelligently manipulate cell state. Our research is highly interdisciplinary. The methods we use range from molecular modeling of protein structures, to bioinformatics analysis of epigenomic data generated by sequencing technology, to statistical learning of genetic network, to biophysical modeling of epigenetic landscape. The theoretical work is tightly coupled with experimental investigation that exploits molecular biology, biochemistry, cell biology and genomic techniques. © 2018 Wang lab. Contact webmaster ....